Selpercatinib

CHEMBL4559134 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

525.6 g/mol

LogP

2.5

Phase

4

Designed specifically for cancers driven by abnormal RET gene fusions or mutations, this targeted oral therapy blocks the faulty RET protein that signals tumor cells to grow. It is used for certain lung, thyroid, and breast cancers and can cross into the brain to treat metastases there.

分子量

525.6000 g/mol

LogP

2.50

TPSA

112.00 Å²

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

COc1ccc(CN2C3CC2CN(c2ccc(-c4cc(OCC(C)(C)O)cn5ncc(C#N)c45)cn2)C3)cn1

InChI

InChI=1S/C29H31N7O3/c1-29(2,37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7,9,11-13,17,22-23,37H,8,14-16,18H2,1-3H3

Molecular Formula

C29H31N7O3

HBD / HBA

1 / 9

可旋转键数

8

重原子数

39

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

Designed specifically for cancers driven by abnormal RET gene fusions or mutations, this targeted oral therapy blocks the faulty RET protein that signals tumor cells to grow. It is used for certain lung, thyroid, and breast cancers and can cross into the brain to treat metastases there.

Yes, Selpercatinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4559134. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 134436906. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C29H31N7O3
同义词: 1

外部链接

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.