Sibutramine

CHEMBL1419 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

279.8 g/mol

LogP

5.4

Phase

4

Sibutramine is a centrally acting serotonin-norepinephrine reuptake inhibitor originally developed as an antidepressant and later used as an anti-obesity agent for weight management. By inhibiting reuptake of serotonin, norepinephrine, and to a lesser extent dopamine, it promotes satiety and reduces food intake while modestly increasing energy expenditure. It was withdrawn from markets in many countries due to increased risk of major adverse cardiovascular events in high-risk patients.

分子量

279.8000 g/mol

LogP

5.40

TPSA

3.20 Å²

Lipinski 五规则

符合

治疗领域

Asthma Schizophrenia Bipolar Disorder Obesity Hypertension Cardiovascular Disease

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1

InChI

InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3

Molecular Formula

C17H26ClN

HBD / HBA

- / 1

可旋转键数

5

重原子数

19

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

Sibutramine is a centrally acting serotonin-norepinephrine reuptake inhibitor originally developed as an antidepressant and later used as an anti-obesity agent for weight management. By inhibiting reuptake of serotonin, norepinephrine, and to a lesser extent dopamine, it promotes satiety and reduces food intake while modestly increasing energy expenditure. It was withdrawn from markets in many countries due to increased risk of major adverse cardiovascular events in high-risk patients.

Yes, Sibutramine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1419. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5210. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C17H26ClN

外部链接

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.