Sofpironium
Sofpironium is a novel anticholinergic agent in the form of a soft drug specifically designed for topical application to reduce sweating in primary axillary hyperhidrosis. By blocking muscarinic acetylcholine receptors on eccrine sweat glands, it inhibits sweat secretion locally, with its retro-metabolic design ensuring rapid systemic inactivation to minimize systemic anticholinergic side effects. It is applied topically as a gel formulation.
分子量
390.5000 g/mol
LogP
3.30
TPSA
72.80 Ų
Lipinski 五规则
符合
作用机制
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
二维结构
Cite this structure
Embed this structure
SMILES
CCOC(=O)C[N+]1(C)CC[C@@H](OC(=O)[C@](O)(c2ccccc2)C2CCCC2)C1
InChI
InChI=1S/C22H32NO5/c1-3-27-20(24)16-23(2)14-13-19(15-23)28-21(25)22(26,18-11-7-8-12-18)17-9-5-4-6-10-17/h4-6,9-10,18-19,26H,3,7-8,11-16H2,1-2H3/q+1/t19-,22+,23?/m1/s1
Molecular Formula
C22H32NO5+
HBD / HBA
1 / 5
可旋转键数
9
重原子数
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Sofpironium is a novel anticholinergic agent in the form of a soft drug specifically designed for topical application to reduce sweating in primary axillary hyperhidrosis. By blocking muscarinic acetylcholine receptors on eccrine sweat glands, it inhibits sweat secretion locally, with its retro-metabolic design ensuring rapid systemic inactivation to minimize systemic anticholinergic side effects. It is applied topically as a gel formulation.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Sofpironium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3707224. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 86301317. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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