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Solriamfetol

CHEMBL4297620 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
194.2 g/mol
LogP
0.6
Phase
4

Solriamfetol is a dopamine and norepinephrine reuptake inhibitor (DNRI) used to improve wakefulness in adults with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea, and investigated for major depressive disorder comorbid with sleep disorders. By inhibiting the dopamine and norepinephrine transporters (DAT and NET), it promotes wake-promoting neurotransmission in arousal circuits without the serotonergic effects of amphetamines. It has a lower abuse potential than traditional stimulants but is classified as a Schedule IV controlled substance.

分子量

194.2300 g/mol

LogP

0.60

TPSA

78.30 Ų

Lipinski 五规则

符合

治疗领域

Insomnia Multiple Sclerosis Major Depressive Disorder

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
NC(=O)OC[C@H](N)Cc1ccccc1

                

                

                
                

                    
InChI

                    
InChI=1S/C10H14N2O2/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H2,12,13)/t9-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H14N2O2

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
可旋转键数

                        
5

                    

                    
                    
                    

                        
重原子数

                        
14

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
Solriamfetol is a dopamine and norepinephrine reuptake inhibitor (DNRI) used to improve wakefulness in adults with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea, and investigated for major depressive disorder comorbid with sleep disorders. By inhibiting the dopamine and norepinephrine transporters (DAT and NET), it promotes wake-promoting neurotransmission in arousal circuits without the serotonergic effects of amphetamines. It has a lower abuse potential than traditional stimulants but is classified as a Schedule IV controlled substance.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Solriamfetol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL4297620.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 10130337.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.