Technetium (99Mtc) Apcitide
Technetium (99mTc) apcitide is a radiolabeled synthetic peptide that binds to the glycoprotein IIb/IIIa (αIIbβ3) receptor on activated platelets, enabling scintigraphic imaging of acute venous thrombosis. The technetium-99m radiolabel emits gamma radiation detectable by a gamma camera, allowing non-invasive localization of thrombi in the deep veins. It represents a targeted nuclear medicine imaging approach for thrombus detection.
分子量
1525.5000 g/mol
TPSA
688.00 Ų
Pharmacokinetics (PK)
Pharmacodynamics (PD)
SMILES
CC(=O)NCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCNC(=O)C)C(=NCC(=NCC(=N[C@@H](C[S-])C(=O)N)[O-])[O-])[O-])NC(=O)CNC(=O)CNC(=O)[C@@H]1CSCC(=O)N[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N1)CC(=O)[O-])CSCCCN)CC2=CC=C(C=C2)O.[O-2].[Na+].[99Tc+5]
InChI
InChI=1S/C51H77N17O19S5.Na.O.Tc/c1-26(69)60-24-91-21-33(46(82)56-12-37(72)54-14-39(74)64-32(18-88)45(53)81)66-42(77)17-58-47(83)34(22-92-25-61-27(2)70)65-40(75)15-55-38(73)13-57-49(85)36-20-90-23-43(78)63-30(10-28-4-6-29(71)7-5-28)50(86)67-35(19-89-9-3-8-52)48(84)59-16-41(76)62-31(11-44(79)80)51(87)68-36;;;/h4-7,30-36,71,88H,3,8-25,52H2,1-2H3,(H2,53,81)(H,54,72)(H,55,73)(H,56,82)(H,57,85)(H,58,83)(H,59,84)(H,60,69)(H,61,70)(H,62,76)(H,63,78)(H,64,74)(H,65,75)(H,66,77)(H,67,86)(H,68,87)(H,79,80);;;/q;+1;-2;+5/p-5/t30-,31+,32+,33+,34+,35+,36+;;;/m1.../s1/i;;;1+1
Molecular Formula
C51H72N17NaO20S5Tc-
HBD / HBA
15 / 29
可旋转键数
34
重原子数
95
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Technetium (99mTc) apcitide is a radiolabeled synthetic peptide that binds to the glycoprotein IIb/IIIa (αIIbβ3) receptor on activated platelets, enabling scintigraphic imaging of acute venous thrombosis. The technetium-99m radiolabel emits gamma radiation detectable by a gamma camera, allowing non-invasive localization of thrombi in the deep veins. It represents a targeted nuclear medicine imaging approach for thrombus detection.
Yes, Technetium (99Mtc) Apcitide is an approved drug. It has reached clinical phase 4. It is classified as a Protein.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201524. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 72941734. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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