Tipranavir
This antiretroviral medication is a protease inhibitor used as part of combination therapy to treat HIV infection in adults and children who have already been treated with other HIV medications and whose virus has become resistant to them. It must always be combined with a low dose of ritonavir to reach effective blood levels. Serious liver toxicity can occur, so liver function must be carefully monitored.
分子量
602.7000 g/mol
LogP
7.00
TPSA
114.00 Ų
Lipinski 五规则
不符合
治疗领域
作用机制
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
二维结构
Cite this structure
Embed this structure
SMILES
CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1
InChI
InChI=1S/C31H33F3N2O5S/c1-3-16-30(17-15-21-9-6-5-7-10-21)19-26(37)28(29(38)41-30)25(4-2)22-11-8-12-24(18-22)36-42(39,40)27-14-13-23(20-35-27)31(32,33)34/h5-14,18,20,25,36-37H,3-4,15-17,19H2,1-2H3/t25-,30-/m1/s1
Molecular Formula
C31H33F3N2O5S
HBD / HBA
2 / 10
可旋转键数
11
重原子数
42
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
This antiretroviral medication is a protease inhibitor used as part of combination therapy to treat HIV infection in adults and children who have already been treated with other HIV medications and whose virus has become resistant to them. It must always be combined with a low dose of ritonavir to reach effective blood levels. Serious liver toxicity can occur, so liver function must be carefully monitored.
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Yes, Tipranavir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL222559. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 54682461. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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