Trametinib Dimethyl Sulfoxide
Trametinib dimethyl sulfoxide is the dimethyl sulfoxide solvate form of trametinib, an allosteric MEK1/MEK2 inhibitor used in combination with BRAF inhibitors for BRAF-mutated cancers. See trametinib for complete pharmacological details. This solvate form is the pharmaceutical formulation used in approved oral tablets.
分子量
693.5000 g/mol
TPSA
138.00 Ų
治疗领域
作用机制
Inhibits BRAF kinase, a key component of the RAS/MAPK signaling pathway, blocking constitutive activation that drives cancer cell proliferation in tumors harboring BRAF mutations.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits BRAF kinase, a key component of the RAS/MAPK signaling pathway, blocking constitutive activation that drives cancer cell proliferation in tumors harboring BRAF mutations.
二维结构
Cite this structure
Embed this structure
SMILES
CC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1.C[S+](C)[O-]
InChI
InChI=1S/C26H23FIN5O4.C2H6OS/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34;1-4(2)3/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34);1-2H3
Molecular Formula
C28H29FIN5O5S
HBD / HBA
2 / 8
可旋转键数
5
重原子数
41
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Trametinib dimethyl sulfoxide is the dimethyl sulfoxide solvate form of trametinib, an allosteric MEK1/MEK2 inhibitor used in combination with BRAF inhibitors for BRAF-mutated cancers. See trametinib for complete pharmacological details. This solvate form is the pharmaceutical formulation used in approved oral tablets.
Inhibits BRAF kinase, a key component of the RAS/MAPK signaling pathway, blocking constitutive activation that drives cancer cell proliferation in tumors harboring BRAF mutations.
Yes, Trametinib Dimethyl Sulfoxide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105741. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 50992434. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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