Trifluoperazine
Trifluoperazine is a high-potency phenothiazine typical antipsychotic that blocks dopamine D2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular pathways, producing antipsychotic effects through reduction of dopaminergic transmission. It is used for schizophrenia, short-term treatment of generalized anxiety disorder, and nausea/vomiting, and also blocks histamine H1, muscarinic, and alpha-adrenergic receptors. Its high D2 affinity is associated with a high rate of extrapyramidal adverse effects including parkinsonism and tardive dyskinesia.
分子量
407.5000 g/mol
LogP
5.00
TPSA
35.00 Ų
Lipinski 五规则
符合
治疗领域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
CN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
InChI
InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3
Molecular Formula
C21H24F3N3S
HBD / HBA
- / 7
可旋转键数
4
重原子数
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Trifluoperazine is a high-potency phenothiazine typical antipsychotic that blocks dopamine D2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular pathways, producing antipsychotic effects through reduction of dopaminergic transmission. It is used for schizophrenia, short-term treatment of generalized anxiety disorder, and nausea/vomiting, and also blocks histamine H1, muscarinic, and alpha-adrenergic receptors. Its high D2 affinity is associated with a high rate of extrapyramidal adverse effects including parkinsonism and tardive dyskinesia.
Yes, Trifluoperazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL422. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5566. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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