Tromethamine
Tromethamine (TRIS) is an alkalinizing agent that buffers metabolic acidosis by accepting protons and increasing urinary pH, used in conditions such as cardiac surgery, respiratory acidosis, and metabolic acidosis. It is also used as a pharmaceutical excipient and as a salt-forming agent in drug formulations (e.g., ketorolac tromethamine) to enhance solubility. Its buffering capacity does not require carbon dioxide excretion, making it useful in patients with impaired ventilation.
分子量
121.1400 g/mol
LogP
-2.90
TPSA
86.70 Ų
Lipinski 五规则
符合
治疗领域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
NC(CO)(CO)CO
InChI
InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
Molecular Formula
C4H11NO3
HBD / HBA
4 / 4
可旋转键数
3
重原子数
8
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Tromethamine (TRIS) is an alkalinizing agent that buffers metabolic acidosis by accepting protons and increasing urinary pH, used in conditions such as cardiac surgery, respiratory acidosis, and metabolic acidosis. It is also used as a pharmaceutical excipient and as a salt-forming agent in drug formulations (e.g., ketorolac tromethamine) to enhance solubility. Its buffering capacity does not require carbon dioxide excretion, making it useful in patients with impaired ventilation.
Yes, Tromethamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200391. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6503. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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