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Uracil Mustard

CHEMBL1488 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
252.1 g/mol
LogP
0.5
Phase
4

Uracil mustard is an alkylating antineoplastic agent that combines a uracil base with a nitrogen mustard moiety, enabling it to cross-link DNA strands and inhibit DNA replication in rapidly proliferating cancer cells. It was used orally for treatment of chronic lymphocytic leukemia, non-Hodgkin lymphoma, and other hematologic malignancies, as well as certain solid tumors including breast cancer. It has largely been replaced by more targeted therapies but served as an important early oral alkylating agent.

分子量

252.0900 g/mol

LogP

0.50

TPSA

61.40 Ų

Lipinski 五规则

符合

治疗领域

Melanoma Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Pain Management Non-Small Cell Lung Cancer Lymphoma Breast Cancer Chronic Pain Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Oc1ncc(N(CCCl)CCCl)c(O)n1

                

                

                
                

                    
InChI

                    
InChI=1S/C8H11Cl2N3O2/c9-1-3-13(4-2-10)6-5-11-8(15)12-7(6)14/h5H,1-4H2,(H2,11,12,14,15)

                

                

                

                    
                    

                        
Molecular Formula

                        
C8H11Cl2N3O2

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
可旋转键数

                        
5

                    

                    
                    
                    

                        
重原子数

                        
15

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
Uracil mustard is an alkylating antineoplastic agent that combines a uracil base with a nitrogen mustard moiety, enabling it to cross-link DNA strands and inhibit DNA replication in rapidly proliferating cancer cells. It was used orally for treatment of chronic lymphocytic leukemia, non-Hodgkin lymphoma, and other hematologic malignancies, as well as certain solid tumors including breast cancer. It has largely been replaced by more targeted therapies but served as an important early oral alkylating agent.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Uracil Mustard is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1488.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6194.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.