Vemurafenib
This targeted therapy is used to treat melanoma that has spread to other parts of the body and carries a specific mutation in the BRAF gene (V600E). It works by blocking the mutated BRAF protein that tells cancer cells to grow uncontrollably. Resistance often develops within months of starting treatment, so it is sometimes combined with MEK inhibitors to prolong effectiveness.
分子量
489.9000 g/mol
LogP
5.00
TPSA
100.00 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Inhibits BRAF kinase, a key component of the RAS/MAPK signaling pathway, blocking constitutive activation that drives cancer cell proliferation in tumors harboring BRAF mutations.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits BRAF kinase, a key component of the RAS/MAPK signaling pathway, blocking constitutive activation that drives cancer cell proliferation in tumors harboring BRAF mutations.
二维结构
Cite this structure
Embed this structure
SMILES
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F
InChI
InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
Molecular Formula
C23H18ClF2N3O3S
HBD / HBA
2 / 7
可旋转键数
7
重原子数
33
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
This targeted therapy is used to treat melanoma that has spread to other parts of the body and carries a specific mutation in the BRAF gene (V600E). It works by blocking the mutated BRAF protein that tells cancer cells to grow uncontrollably. Resistance often develops within months of starting treatment, so it is sometimes combined with MEK inhibitors to prolong effectiveness.
Inhibits BRAF kinase, a key component of the RAS/MAPK signaling pathway, blocking constitutive activation that drives cancer cell proliferation in tumors harboring BRAF mutations.
Yes, Vemurafenib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1229517. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 42611257. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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