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Vinblastine

CHEMBL159 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
811.0 g/mol
LogP
3.7
Phase
4

This chemotherapy drug derived from the periwinkle plant (Vinca rosea) is used to treat cancers including Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, bladder cancer, and breast cancer. It works by interfering with the formation of the mitotic spindle, a structure cancer cells need to divide and multiply. It can cause peripheral neuropathy (tingling and numbness in hands and feet) and must not be given by spinal injection as this is fatal.

分子量

811.0000 g/mol

LogP

3.70

TPSA

154.00 Ų

Lipinski 五规则

不符合

治疗领域

Melanoma Ovarian Cancer Pancreatic Cancer Bladder Cancer Non-Small Cell Lung Cancer Lymphoma Breast Cancer Prostate Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1

                

                

                
                

                    
InChI

                    
InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C46H58N4O9

                    

                    
                    

                        
HBD / HBA

                        
3 / 12

                    

                    
                    

                        
可旋转键数

                        
10

                    

                    
                    
                    

                        
重原子数

                        
59

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
This chemotherapy drug derived from the periwinkle plant (Vinca rosea) is used to treat cancers including Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, bladder cancer, and breast cancer. It works by interfering with the formation of the mitotic spindle, a structure cancer cells need to divide and multiply. It can cause peripheral neuropathy (tingling and numbness in hands and feet) and must not be given by spinal injection as this is fatal.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Vinblastine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL159.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 13342.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.