Vonoprazan Fumarate

CHEMBL2064032 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

461.5 g/mol

LogP

—

Phase

4

Vonoprazan fumarate is the fumarate salt form of vonoprazan, a potassium-competitive acid blocker used for acid-related gastrointestinal disorders including GERD and H. pylori eradication. The fumarate salt provides optimal solubility and stability for oral tablet formulation. Like the free base, it provides superior and more consistent gastric acid suppression compared to conventional PPIs through its potassium-competitive mechanism at the proton pump.

分子量

461.5000 g/mol

TPSA

147.00 Å²

治疗领域

Hypertension

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

CNCc1cc(-c2ccccc2F)n(S(=O)(=O)c2cccnc2)c1.O=C(O)/C=C/C(=O)O

InChI

InChI=1S/C17H16FN3O2S.C4H4O4/c1-19-10-13-9-17(15-6-2-3-7-16(15)18)21(12-13)24(22,23)14-5-4-8-20-11-14;5-3(6)1-2-4(7)8/h2-9,11-12,19H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

Molecular Formula

C21H20FN3O6S

HBD / HBA

3 / 9

可旋转键数

7

重原子数

32

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

Vonoprazan fumarate is the fumarate salt form of vonoprazan, a potassium-competitive acid blocker used for acid-related gastrointestinal disorders including GERD and H. pylori eradication. The fumarate salt provides optimal solubility and stability for oral tablet formulation. Like the free base, it provides superior and more consistent gastric acid suppression compared to conventional PPIs through its potassium-competitive mechanism at the proton pump.

Yes, Vonoprazan Fumarate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2064032. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 45375887. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C21H20FN3O6S
同义词: 2

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.