Voriconazole
This broad-spectrum antifungal medication is used to treat serious and potentially life-threatening fungal infections, particularly invasive aspergillosis and certain other mold and yeast infections in immunocompromised patients such as those undergoing bone marrow transplants. It is available in both oral and intravenous forms and works by blocking a key enzyme in the fungal cell membrane synthesis pathway. It interacts with many medications and can cause visual disturbances, liver toxicity, and sun sensitivity.
分子量
349.3100 g/mol
LogP
1.50
TPSA
76.70 Ų
Lipinski 五规则
符合
治疗领域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F
InChI
InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
Molecular Formula
C16H14F3N5O
HBD / HBA
1 / 8
可旋转键数
5
重原子数
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
This broad-spectrum antifungal medication is used to treat serious and potentially life-threatening fungal infections, particularly invasive aspergillosis and certain other mold and yeast infections in immunocompromised patients such as those undergoing bone marrow transplants. It is available in both oral and intravenous forms and works by blocking a key enzyme in the fungal cell membrane synthesis pathway. It interacts with many medications and can cause visual disturbances, liver toxicity, and sun sensitivity.
Yes, Voriconazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL638. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 71616. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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