Voxelotor
Voxelotor is a hemoglobin S (HbS) polymerization inhibitor that covalently and reversibly binds to the alpha-chain of hemoglobin, increasing hemoglobin oxygen affinity and stabilizing the oxygenated state to prevent HbS sickling and polymer formation in red blood cells. It is approved for sickle cell disease in patients aged 4 years and older to increase hemoglobin levels and reduce hemolysis. By preventing red blood cell sickling, it improves anemia and reduces vaso-occlusive complications.
分子量
337.4000 g/mol
LogP
2.70
TPSA
77.20 Ų
Lipinski 五规则
符合
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
CC(C)n1nccc1-c1ncccc1COc1cccc(O)c1C=O
InChI
InChI=1S/C19H19N3O3/c1-13(2)22-16(8-10-21-22)19-14(5-4-9-20-19)12-25-18-7-3-6-17(24)15(18)11-23/h3-11,13,24H,12H2,1-2H3
Molecular Formula
C19H19N3O3
HBD / HBA
1 / 5
可旋转键数
6
重原子数
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Voxelotor is a hemoglobin S (HbS) polymerization inhibitor that covalently and reversibly binds to the alpha-chain of hemoglobin, increasing hemoglobin oxygen affinity and stabilizing the oxygenated state to prevent HbS sickling and polymer formation in red blood cells. It is approved for sickle cell disease in patients aged 4 years and older to increase hemoglobin levels and reduce hemolysis. By preventing red blood cell sickling, it improves anemia and reduces vaso-occlusive complications.
Yes, Voxelotor is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4101807. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 71602803. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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