Zileuton
Zileuton is a 5-lipoxygenase (5-LOX) inhibitor that blocks the enzyme responsible for converting arachidonic acid to 5-hydroperoxyeicosatetraenoic acid (5-HPETE) and subsequently to leukotrienes, potent inflammatory mediators that cause bronchoconstriction, mucus secretion, and inflammatory cell recruitment in asthma. It is approved for the prophylaxis and chronic treatment of asthma, reducing leukotriene-mediated airway inflammation and bronchoconstriction. Its direct enzyme inhibition of leukotriene synthesis distinguishes it from leukotriene receptor antagonists like montelukast.
分子量
236.2900 g/mol
LogP
1.60
TPSA
94.80 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
二维结构
Cite this structure
Embed this structure
SMILES
CC(c1cc2ccccc2s1)N(O)C(N)=O
InChI
InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
Molecular Formula
C11H12N2O2S
HBD / HBA
2 / 3
可旋转键数
2
重原子数
16
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Zileuton is a 5-lipoxygenase (5-LOX) inhibitor that blocks the enzyme responsible for converting arachidonic acid to 5-hydroperoxyeicosatetraenoic acid (5-HPETE) and subsequently to leukotrienes, potent inflammatory mediators that cause bronchoconstriction, mucus secretion, and inflammatory cell recruitment in asthma. It is approved for the prophylaxis and chronic treatment of asthma, reducing leukotriene-mediated airway inflammation and bronchoconstriction. Its direct enzyme inhibition of leukotriene synthesis distinguishes it from leukotriene receptor antagonists like montelukast.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Zileuton is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL93. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 60490. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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