Major
Probable
描述
Azithromycin and escitalopram each prolong the QT interval; co-administration meaningfully increases the risk of torsades de pointes.
机制
Both agents block cardiac hERG (IKr) channels; additive QTc prolongation may exceed the threshold for proarrhythmic risk.
临床意义
FDA QT safety communications exist for both agents independently; case reports link the combination to arrhythmic events.
处理措施
Avoid concurrent use when possible; if unavoidable, obtain ECG, correct hypokalemia/hypomagnesemia, and limit duration of azithromycin course.