Moderate
Established
描述
Ibuprofen reduces the diuretic and antihypertensive efficacy of spironolactone and may exacerbate renal insufficiency in high-risk patients.
机制
NSAIDs inhibit prostaglandin synthesis, causing sodium retention and reducing the natriuretic effect of spironolactone; together they impair renal tubular secretion and glomerular filtration.
临床意义
Clinically significant in patients with heart failure where diuretic response is critical; fluid overload and cardiac decompensation can result.
处理措施
Avoid NSAIDs in spironolactone-treated patients; monitor renal function and electrolytes closely if co-administration is unavoidable.