January
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February
一二三周四周五周六周日
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March
一二三周四周五周六周日
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April
一二三周四周五周六周日
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May
一二三周四周五周六周日
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June
一二三周四周五周六周日
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July
一二三周四周五周六周日
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August
一二三周四周五周六周日
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September
一二三周四周五周六周日
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October
一二三周四周五周六周日
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November
一二三周四周五周六周日
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December
一二三周四周五周六周日
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31
事件密度：
1-5
6-9
10-12
13+
1998年的事件
—
1998: Trastuzumab (Herceptin): HER2-Targeted Therapy (1998)
Landmark Approval
Trastuzumab demonstrated that an oncogenic driver gene—present in a defined patient subset— could be pharmacologically silenced with a [[term:monoclonal-antibody|monoclonal antibody]], …
—
1998: Sildenafil: Serendipitous PDE5 Discovery (1998)
Landmark Approval
Sildenafil illustrated that rigorous attention to unexpected clinical signals during trials can salvage—and dramatically redirect—a failing programme. It created the …