Captopril vs Enalapril

## Captopril vs Enalapril: Overview

This comparison examines the pharmacological differences between **Captopril** and **Enalapril**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Enalapril**: Prodrug converted to enalaprilat; inhibits ACE preventing angiotensin I to II conversion.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Enalapril — 11 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Enalapril — C20H28N2O5.

**Molecular Weight**: Captopril — 217.2850 g/mol; Enalapril — 376.4470 g/mol.

**Type**: Captopril — Small molecule; Enalapril — Small molecule.