Captopril vs Enalapril

Captopril vs Enalapril: Overview

This comparison examines the pharmacological differences between Captopril and Enalapril.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Enalapril: Prodrug converted to enalaprilat; inhibits ACE preventing angiotensin I to II conversion.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Enalapril — 11 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Enalapril — C20H28N2O5.

Molecular Weight: Captopril — 217.2850 g/mol; Enalapril — 376.4470 g/mol.

Type: Captopril — Small molecule; Enalapril — Small molecule.