Captopril vs Irbesartan

## Captopril vs Irbesartan: Overview

This comparison examines the pharmacological differences between **Captopril** and **Irbesartan**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Irbesartan**: Selective non-competitive angiotensin II type 1 receptor antagonist.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Irbesartan — 11-15 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Irbesartan — C25H28N6O.

**Molecular Weight**: Captopril — 217.2850 g/mol; Irbesartan — 428.5320 g/mol.

**Type**: Captopril — Small molecule; Irbesartan — Small molecule.