Captopril vs Irbesartan

Captopril vs Irbesartan: Overview

This comparison examines the pharmacological differences between Captopril and Irbesartan.

Mechanism of Action

Captopril: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

Irbesartan: Selective non-competitive angiotensin II type 1 receptor antagonist.

Pharmacokinetics

Half-life: Captopril — 1.9 hours; Irbesartan — 11-15 hours.

Chemical Properties

Molecular Formula: Captopril — C9H15NO3S; Irbesartan — C25H28N6O.

Molecular Weight: Captopril — 217.2850 g/mol; Irbesartan — 428.5320 g/mol.

Type: Captopril — Small molecule; Irbesartan — Small molecule.