Dexamethasone vs Tofacitinib

## Dexamethasone vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Dexamethasone** and **Tofacitinib**.

## Mechanism of Action

**Dexamethasone**: Potent synthetic glucocorticoid.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Dexamethasone — 36-54 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Dexamethasone — C22H29FO5; Tofacitinib — C16H20N6O.

**Molecular Weight**: Dexamethasone — 392.4610 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Dexamethasone — Small molecule; Tofacitinib — Small molecule.