Dexamethasone vs Tofacitinib

Dexamethasone vs Tofacitinib: Overview

This comparison examines the pharmacological differences between Dexamethasone and Tofacitinib.

Mechanism of Action

Dexamethasone: Potent synthetic glucocorticoid.

Tofacitinib: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

Pharmacokinetics

Half-life: Dexamethasone — 36-54 hours; Tofacitinib — 3.2 hours.

Chemical Properties

Molecular Formula: Dexamethasone — C22H29FO5; Tofacitinib — C16H20N6O.

Molecular Weight: Dexamethasone — 392.4610 g/mol; Tofacitinib — 312.3700 g/mol.

Type: Dexamethasone — Small molecule; Tofacitinib — Small molecule.