Digoxin vs Hydrochlorothiazide

## Digoxin vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between **Digoxin** and **Hydrochlorothiazide**.

## Mechanism of Action

**Digoxin**: Inhibits Na+/K+-ATPase, increasing intracellular calcium.

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

## Pharmacokinetics

**Half-life**: Digoxin — 36-48 hours; Hydrochlorothiazide — 6-15 hours.

## Chemical Properties

**Molecular Formula**: Digoxin — C41H64O14; Hydrochlorothiazide — C7H8ClN3O4S2.

**Molecular Weight**: Digoxin — 780.9430 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

**Type**: Digoxin — Small molecule; Hydrochlorothiazide — Small molecule.