Digoxin vs Hydrochlorothiazide

Digoxin vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between Digoxin and Hydrochlorothiazide.

Mechanism of Action

Digoxin: Inhibits Na+/K+-ATPase, increasing intracellular calcium.

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Pharmacokinetics

Half-life: Digoxin — 36-48 hours; Hydrochlorothiazide — 6-15 hours.

Chemical Properties

Molecular Formula: Digoxin — C41H64O14; Hydrochlorothiazide — C7H8ClN3O4S2.

Molecular Weight: Digoxin — 780.9430 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

Type: Digoxin — Small molecule; Hydrochlorothiazide — Small molecule.