Hydrochlorothiazide vs Hydroxychloroquine

## Hydrochlorothiazide vs Hydroxychloroquine: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Hydroxychloroquine**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Hydroxychloroquine**: Accumulates in lysosomes raising pH; inhibits toll-like receptor signaling.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Hydroxychloroquine — 40-50 days.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Hydroxychloroquine — C18H26ClN3O.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Hydroxychloroquine — 335.8720 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Hydroxychloroquine — Small molecule.