Hydrochlorothiazide vs Hydroxychloroquine

Hydrochlorothiazide vs Hydroxychloroquine: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Hydroxychloroquine.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Hydroxychloroquine: Accumulates in lysosomes raising pH; inhibits toll-like receptor signaling.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Hydroxychloroquine — 40-50 days.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Hydroxychloroquine — C18H26ClN3O.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Hydroxychloroquine — 335.8720 g/mol.

Type: Hydrochlorothiazide — Small molecule; Hydroxychloroquine — Small molecule.