Hydrochlorothiazide vs Loratadine

## Hydrochlorothiazide vs Loratadine: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Loratadine**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Loratadine**: Second-generation H1 antihistamine with minimal CNS effects.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Loratadine — 8 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Loratadine — C22H23ClN2O2.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Loratadine — 382.8800 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Loratadine — Small molecule.