Hydrochlorothiazide vs Loratadine

Hydrochlorothiazide vs Loratadine: Overview

This comparison examines the pharmacological differences between Hydrochlorothiazide and Loratadine.

Mechanism of Action

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Loratadine: Second-generation H1 antihistamine with minimal CNS effects.

Pharmacokinetics

Half-life: Hydrochlorothiazide — 6-15 hours; Loratadine — 8 hours.

Chemical Properties

Molecular Formula: Hydrochlorothiazide — C7H8ClN3O4S2; Loratadine — C22H23ClN2O2.

Molecular Weight: Hydrochlorothiazide — 297.7400 g/mol; Loratadine — 382.8800 g/mol.

Type: Hydrochlorothiazide — Small molecule; Loratadine — Small molecule.