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Chlorthalidone

CHEMBL1055 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
338.8 g/mol
LogP
0.9
Phase
4

A thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal nephron, producing a longer duration of action than conventional thiazides such as hydrochlorothiazide. It is used to treat hypertension and is considered by many guidelines to be a preferred diuretic choice due to its superior evidence base for reducing cardiovascular events. Electrolyte disturbances, particularly hypokalemia, require periodic monitoring.

الوزن الجزيئي

338,8000 g/mol

LogP

0,90

TPSA

118,00 Ų

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Cardiovascular Disease Chronic Kidney Disease Obesity Type 2 Diabetes Hypertension Heart Failure

آلية العمل

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

البنية ثنائية الأبعاد

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Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
NS(=O)(=O)c1cc(C2(O)NC(=O)c3ccccc32)ccc1Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H11ClN2O4S

                    

                    
                    

                        
HBD / HBA

                        
3 / 5

                    

                    
                    

                        
الروابط القابلة للدوران

                        
2

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
A thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal nephron, producing a longer duration of action than conventional thiazides such as hydrochlorothiazide. It is used to treat hypertension and is considered by many guidelines to be a preferred diuretic choice due to its superior evidence base for reducing cardiovascular events. Electrolyte disturbances, particularly hypokalemia, require periodic monitoring.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Chlorthalidone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1055.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2732.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.