Chlorthalidone
A thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal nephron, producing a longer duration of action than conventional thiazides such as hydrochlorothiazide. It is used to treat hypertension and is considered by many guidelines to be a preferred diuretic choice due to its superior evidence base for reducing cardiovascular events. Electrolyte disturbances, particularly hypokalemia, require periodic monitoring.
Molecular Weight
338.8000 g/mol
LogP
0.90
TPSA
118.00 Ų
Lipinski RO5
Pass
Therapeutic Areas
Mechanism of Action
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
2D Structure
Cite this structure
Embed this structure
SMILES
NS(=O)(=O)c1cc(C2(O)NC(=O)c3ccccc32)ccc1Cl
InChI
InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)
Molecular Formula
C14H11ClN2O4S
HBD / HBA
3 / 5
Rotatable Bonds
2
Heavy Atoms
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Frequently Asked Questions
A thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal nephron, producing a longer duration of action than conventional thiazides such as hydrochlorothiazide. It is used to treat hypertension and is considered by many guidelines to be a preferred diuretic choice due to its superior evidence base for reducing cardiovascular events. Electrolyte disturbances, particularly hypokalemia, require periodic monitoring.
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Yes, Chlorthalidone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1055. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2732. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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