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Dihydroergotamine

CHEMBL1732 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
583.7 g/mol
LogP
2.4
Phase
4

An ergot-derived medication used to treat acute migraine and cluster headache attacks by constricting blood vessels and modulating serotonin and adrenergic receptors. It is available as a nasal spray and injectable form. It should not be used within 24 hours of triptans and is contraindicated in people with cardiovascular disease due to its vasoconstrictive effects.

الوزن الجزيئي

583,7000 g/mol

LogP

2,40

TPSA

118,00 Ų

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Non-Small Cell Lung Cancer Migraine

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21

                

                

                
                

                    
InChI

                    
InChI=1S/C33H37N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39)/t21-,23-,25-,26+,27+,32-,33+/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C33H37N5O5

                    

                    
                    

                        
HBD / HBA

                        
3 / 6

                    

                    
                    

                        
الروابط القابلة للدوران

                        
4

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
43

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
An ergot-derived medication used to treat acute migraine and cluster headache attacks by constricting blood vessels and modulating serotonin and adrenergic receptors. It is available as a nasal spray and injectable form. It should not be used within 24 hours of triptans and is contraindicated in people with cardiovascular disease due to its vasoconstrictive effects.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Dihydroergotamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1732.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 10531.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.