Dihydroergotamine

CHEMBL1732 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

583.7 g/mol

LogP

2.4

Phase

4

An ergot-derived medication used to treat acute migraine and cluster headache attacks by constricting blood vessels and modulating serotonin and adrenergic receptors. It is available as a nasal spray and injectable form. It should not be used within 24 hours of triptans and is contraindicated in people with cardiovascular disease due to its vasoconstrictive effects.

Moleküler Ağırlık

583,7000 g/mol

LogP

2,40

TPSA

118,00 Å²

Lipinski RO5

Geçer

Terapötik Alanlar

Non-Small Cell Lung Cancer Migraine

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

SVG PNG

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SMILES

CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21

InChI

InChI=1S/C33H37N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39)/t21-,23-,25-,26+,27+,32-,33+/m1/s1

Molecular Formula

C33H37N5O5

HBD / HBA

3 / 6

Döndürülebilir Bağlar

4

Ağır Atomlar

43

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

An ergot-derived medication used to treat acute migraine and cluster headache attacks by constricting blood vessels and modulating serotonin and adrenergic receptors. It is available as a nasal spray and injectable form. It should not be used within 24 hours of triptans and is contraindicated in people with cardiovascular disease due to its vasoconstrictive effects.

Yes, Dihydroergotamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1732. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 10531. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Dihydroergotamine PillFYI'da

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Hızlı Veriler

Formül: C33H37N5O5
Eş Anlamlılar: 4

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Tıbbi Sorumluluk Reddi

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.