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Protriptyline

CHEMBL668 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
263.4 g/mol
LogP
4.4
Phase
4

Protriptyline is a secondary amine tricyclic antidepressant (TCA) that inhibits the neuronal reuptake of serotonin and norepinephrine by blocking their respective transporters, thereby increasing monoaminergic neurotransmission in the CNS. It is used for the treatment of major depressive disorder and is notable among TCAs for its activating rather than sedating properties, and has also been used for attention deficit disorder and sleep apnea.

الوزن الجزيئي

263,4000 g/mol

LogP

4,40

TPSA

12,00 Ų

قاعدة ليبينسكي للخمسة

ناجح

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CNCCCC1c2ccccc2C=Cc2ccccc21

                

                

                
                

                    
InChI

                    
InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H21N

                    

                    
                    

                        
HBD / HBA

                        
1 / 1

                    

                    
                    

                        
الروابط القابلة للدوران

                        
4

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
20

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
Protriptyline is a secondary amine tricyclic antidepressant (TCA) that inhibits the neuronal reuptake of serotonin and norepinephrine by blocking their respective transporters, thereby increasing monoaminergic neurotransmission in the CNS. It is used for the treatment of major depressive disorder and is notable among TCAs for its activating rather than sedating properties, and has also been used for attention deficit disorder and sleep apnea.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Protriptyline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL668.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4976.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.