Protriptyline

CHEMBL668 Phase 4 Approuvé Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

263.4 g/mol

LogP

4.4

Phase

4

Protriptyline is a secondary amine tricyclic antidepressant (TCA) that inhibits the neuronal reuptake of serotonin and norepinephrine by blocking their respective transporters, thereby increasing monoaminergic neurotransmission in the CNS. It is used for the treatment of major depressive disorder and is notable among TCAs for its activating rather than sedating properties, and has also been used for attention deficit disorder and sleep apnea.

Masse moléculaire

263,4000 g/mol

LogP

4,40

TPSA

12,00 Å²

Règle des 5 de Lipinski

Conforme

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Structure 2D

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SMILES

CNCCCC1c2ccccc2C=Cc2ccccc21

InChI

InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3

Molecular Formula

C19H21N

HBD / HBA

1 / 1

Liaisons Rotatives

4

Atomes Lourds

20

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Foire aux questions

Protriptyline is a secondary amine tricyclic antidepressant (TCA) that inhibits the neuronal reuptake of serotonin and norepinephrine by blocking their respective transporters, thereby increasing monoaminergic neurotransmission in the CNS. It is used for the treatment of major depressive disorder and is notable among TCAs for its activating rather than sedating properties, and has also been used for attention deficit disorder and sleep apnea.

Yes, Protriptyline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL668. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 4976. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Structure

Données Clés

Formule: C19H21N

Liens externes

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Avertissement médical

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.