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Sodium Picosulfate

CHEMBL1697768 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
481.4 g/mol
LogP
—
Phase
4

Sodium picosulfate is a stimulant laxative prodrug that is hydrolyzed by colonic bacteria to the active diphenol, which stimulates intestinal mucosa to increase peristalsis and fluid secretion, used for bowel preparation before colonoscopy and for the treatment of chronic constipation and inflammatory bowel disease. Unlike many osmotic laxatives, it acts locally in the colon and has minimal systemic absorption. It is commonly used in split-dose bowel preparation regimens in combination with magnesium citrate.

الوزن الجزيئي

481,4000 g/mol

TPSA

163,00 Ų

المجالات العلاجية

Inflammatory Bowel Disease Colorectal Cancer

آلية العمل

Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=S(=O)([O-])Oc1ccc(C(c2ccc(OS(=O)(=O)[O-])cc2)c2ccccn2)cc1.[Na+].[Na+]

                

                

                
                

                    
InChI

                    
InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H13NNa2O8S2

                    

                    
                    

                        
HBD / HBA

                        
- / 9

                    

                    
                    

                        
الروابط القابلة للدوران

                        
5

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
31

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
Sodium picosulfate is a stimulant laxative prodrug that is hydrolyzed by colonic bacteria to the active diphenol, which stimulates intestinal mucosa to increase peristalsis and fluid secretion, used for bowel preparation before colonoscopy and for the treatment of chronic constipation and inflammatory bowel disease. Unlike many osmotic laxatives, it acts locally in the colon and has minimal systemic absorption. It is commonly used in split-dose bowel preparation regimens in combination with magnesium citrate.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Sodium Picosulfate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1697768.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 68654.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.