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Tirbanibulin

CHEMBL571546 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
431.5 g/mol
LogP
2.9
Phase
4

Tirbanibulin is a first-in-class dual-mechanism antineoplastic that inhibits both tubulin polymerization (preventing microtubule assembly) and Src kinase signaling (disrupting oncogenic signaling pathways), exerting antiproliferative and anti-invasive effects in tumor cells. It is approved as a topical treatment for actinic keratosis on the face or scalp, and is being investigated for various skin cancers and hematologic malignancies including leukemia. Its dual inhibitory mechanism may overcome some mechanisms of resistance to single-target agents.

الوزن الجزيئي

431,5000 g/mol

LogP

2,90

TPSA

63,70 Ų

قاعدة ليبينسكي للخمسة

ناجح

المجالات العلاجية

Psoriasis Lymphoma Breast Cancer Prostate Cancer Leukemia

آلية العمل

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

الآلية

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=C(Cc1ccc(-c2ccc(OCCN3CCOCC3)cc2)cn1)NCc1ccccc1

                

                

                
                

                    
InChI

                    
InChI=1S/C26H29N3O3/c30-26(28-19-21-4-2-1-3-5-21)18-24-9-6-23(20-27-24)22-7-10-25(11-8-22)32-17-14-29-12-15-31-16-13-29/h1-11,20H,12-19H2,(H,28,30)

                

                

                

                    
                    

                        
Molecular Formula

                        
C26H29N3O3

                    

                    
                    

                        
HBD / HBA

                        
1 / 5

                    

                    
                    

                        
الروابط القابلة للدوران

                        
9

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
32

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
Tirbanibulin is a first-in-class dual-mechanism antineoplastic that inhibits both tubulin polymerization (preventing microtubule assembly) and Src kinase signaling (disrupting oncogenic signaling pathways), exerting antiproliferative and anti-invasive effects in tumor cells. It is approved as a topical treatment for actinic keratosis on the face or scalp, and is being investigated for various skin cancers and hematologic malignancies including leukemia. Its dual inhibitory mechanism may overcome some mechanisms of resistance to single-target agents.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tirbanibulin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL571546.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 23635314.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.