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Vamorolone

CHEMBL2348780 Phase 4 معتمد Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
356.5 g/mol
LogP
2.7
Phase
4

Vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug (DSAID) that structurally mimics glucocorticoids but lacks the 11-beta-hydroxy group, retaining anti-inflammatory efficacy through NF-kB and AP-1 pathway inhibition while reducing glucocorticoid receptor-mediated transactivation side effects. It is approved for Duchenne muscular dystrophy (DMD) to reduce muscle inflammation and slow disease progression with a reduced side effect profile compared to traditional corticosteroids. Its mechanism preserves insulin sensitivity and bone metabolism compared to prednisone.

الوزن الجزيئي

356,5000 g/mol

LogP

2,70

TPSA

74,60 Ų

قاعدة ليبينسكي للخمسة

ناجح

Pharmacokinetics (PK)

Pharmacodynamics (PD)

البنية ثنائية الأبعاد

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@@]1(O)C(=O)CO

                

                

                
                

                    
InChI

                    
InChI=1S/C22H28O4/c1-13-10-18-16-5-4-14-11-15(24)6-8-20(14,2)17(16)7-9-21(18,3)22(13,26)19(25)12-23/h6-8,11,13,16,18,23,26H,4-5,9-10,12H2,1-3H3/t13-,16-,18+,20+,21+,22+/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H28O4

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
الروابط القابلة للدوران

                        
2

                    

                    
                    
                    

                        
الذرات الثقيلة

                        
26

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
الأسئلة الشائعة

                

                    
                    

                        
                        

                            
Vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug (DSAID) that structurally mimics glucocorticoids but lacks the 11-beta-hydroxy group, retaining anti-inflammatory efficacy through NF-kB and AP-1 pathway inhibition while reducing glucocorticoid receptor-mediated transactivation side effects. It is approved for Duchenne muscular dystrophy (DMD) to reduce muscle inflammation and slow disease progression with a reduced side effect profile compared to traditional corticosteroids. Its mechanism preserves insulin sensitivity and bone metabolism compared to prednisone.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Vamorolone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2348780.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3035000.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
إخلاء المسؤولية الطبية

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.