Vamorolone

CHEMBL2348780 Phase 4 Disetujui Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

356.5 g/mol

LogP

2.7

Phase

4

Vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug (DSAID) that structurally mimics glucocorticoids but lacks the 11-beta-hydroxy group, retaining anti-inflammatory efficacy through NF-kB and AP-1 pathway inhibition while reducing glucocorticoid receptor-mediated transactivation side effects. It is approved for Duchenne muscular dystrophy (DMD) to reduce muscle inflammation and slow disease progression with a reduced side effect profile compared to traditional corticosteroids. Its mechanism preserves insulin sensitivity and bone metabolism compared to prednisone.

Berat Molekul

356,5000 g/mol

LogP

2,70

TPSA

74,60 Å²

Lipinski RO5

Lulus

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Struktur 2D

SVG PNG

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SMILES

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@@]1(O)C(=O)CO

InChI

InChI=1S/C22H28O4/c1-13-10-18-16-5-4-14-11-15(24)6-8-20(14,2)17(16)7-9-21(18,3)22(13,26)19(25)12-23/h6-8,11,13,16,18,23,26H,4-5,9-10,12H2,1-3H3/t13-,16-,18+,20+,21+,22+/m1/s1

Molecular Formula

C22H28O4

HBD / HBA

2 / 4

Ikatan yang Dapat Dirotasi

2

Atom Berat

26

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Pertanyaan yang Sering Diajukan

Vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug (DSAID) that structurally mimics glucocorticoids but lacks the 11-beta-hydroxy group, retaining anti-inflammatory efficacy through NF-kB and AP-1 pathway inhibition while reducing glucocorticoid receptor-mediated transactivation side effects. It is approved for Duchenne muscular dystrophy (DMD) to reduce muscle inflammation and slow disease progression with a reduced side effect profile compared to traditional corticosteroids. Its mechanism preserves insulin sensitivity and bone metabolism compared to prednisone.

Yes, Vamorolone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2348780. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 3035000. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Struktur

Data Cepat

Rumus: C22H28O4
Sinonim: 1

Tautan Eksternal

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Penyangkalan Medis

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.