Autoimmune Disease Therapy

Pharmacological strategies aimed at controlling immune-mediated tissue destruction in autoimmune conditions where the immune system attacks self-antigens. Treatment typically follows a stepwise approach: conventional DMARDs (methotrexate), biologic DMARDs (anti-TNF, anti-IL-6), targeted synthetic DMARDs (JAK inhibitors), and corticosteroids for flares. The goal is to achieve remission or low disease activity while minimizing immunosuppression-related infections.

أمثلة

• Methotrexate — first-line DMARD for rheumatoid arthritis
• Belimumab — anti-BLyS for systemic lupus erythematosus
• Upadacitinib — JAK1 inhibitor for RA, atopic dermatitis, ulcerative colitis