Receptor Desensitization
Reduced receptor responsiveness following prolonged or repeated exposure to an agonist. Mechanisms include receptor phosphorylation, internalization, and downregulation. Basis for drug tolerance.
أمثلة
- Beta-2 agonist tachyphylaxis
- Opioid tolerance
- Nicotinic receptor desensitization
هل تعلم؟
Reduced receptor responsiveness following prolonged or repeated exposure to an agonist. Mechanisms include receptor phosphorylation, internalization, and downregulation. Basis for drug tolerance.