Afatinib vs Metformin

## Afatinib vs Metformin: Overview

This comparison examines the pharmacological differences between **Afatinib** and **Metformin**.

## Mechanism of Action

**Afatinib**: Irreversible covalent inhibitor of ErbB family (EGFR/HER1, HER2, HER4) tyrosine kinases.

**Metformin**: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

## Pharmacokinetics

**Half-life**: Afatinib — 37 hours; Metformin — 4-9 hours.

## Chemical Properties

**Molecular Formula**: Afatinib — C24H25ClFN5O3; Metformin — C4H11N5.

**Molecular Weight**: Afatinib — 485.9400 g/mol; Metformin — 129.1640 g/mol.

**Type**: Afatinib — Small molecule; Metformin — Small molecule.