Azithromycin vs Trimethoprim

Azithromycin vs Trimethoprim: Overview

This comparison examines the pharmacological differences between Azithromycin and Trimethoprim.

Mechanism of Action

Azithromycin: Binds 50S ribosomal subunit, inhibiting bacterial protein synthesis.

Trimethoprim: Dihydrofolate reductase inhibitor (bacterial selective).

Pharmacokinetics

Half-life: Azithromycin — 68 hours; Trimethoprim — 8-10 hours.

Chemical Properties

Molecular Formula: Azithromycin — C38H72N2O12; Trimethoprim — C14H18N4O3.

Molecular Weight: Azithromycin — 748.9840 g/mol; Trimethoprim — 290.3180 g/mol.

Type: Azithromycin — Small molecule; Trimethoprim — Small molecule.