Azithromycin vs Trimethoprim

## Azithromycin vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Azithromycin** and **Trimethoprim**.

## Mechanism of Action

**Azithromycin**: Binds 50S ribosomal subunit, inhibiting bacterial protein synthesis.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Azithromycin — 68 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Azithromycin — C38H72N2O12; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Azithromycin — 748.9840 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Azithromycin — Small molecule; Trimethoprim — Small molecule.