Azithromycin vs Vancomycin

Azithromycin vs Vancomycin: Overview

This comparison examines the pharmacological differences between Azithromycin and Vancomycin.

Mechanism of Action

Azithromycin: Binds 50S ribosomal subunit, inhibiting bacterial protein synthesis.

Vancomycin: Glycopeptide antibiotic inhibiting cell wall synthesis by binding D-Ala-D-Ala terminus of peptidoglycan precursors.

Pharmacokinetics

Half-life: Azithromycin — 68 hours; Vancomycin — 4-6 hours.

Chemical Properties

Molecular Formula: Azithromycin — C38H72N2O12; Vancomycin — C66H75Cl2N9O24.

Molecular Weight: Azithromycin — 748.9840 g/mol; Vancomycin — 1449.2500 g/mol.

Type: Azithromycin — Small molecule; Vancomycin — Small molecule.