Buprenorphine vs Hydromorphone

## Buprenorphine vs Hydromorphone: Overview

This comparison examines the pharmacological differences between **Buprenorphine** and **Hydromorphone**.

## Mechanism of Action

**Buprenorphine**: Partial mu-opioid receptor agonist and kappa antagonist with high receptor affinity.

**Hydromorphone**: Semisynthetic mu-opioid receptor agonist approximately 5 times more potent than morphine.

## Pharmacokinetics

**Half-life**: Buprenorphine — 24-42 hours; Hydromorphone — 2-3 hours.

## Chemical Properties

**Molecular Formula**: Buprenorphine — C29H41NO4; Hydromorphone — C17H19NO3.

**Molecular Weight**: Buprenorphine — 467.6430 g/mol; Hydromorphone — 285.3380 g/mol.

**Type**: Buprenorphine — Small molecule; Hydromorphone — Small molecule.