Bupropion vs Duloxetine

Bupropion vs Duloxetine: Overview

This comparison examines the pharmacological differences between Bupropion and Duloxetine.

Mechanism of Action

Bupropion: Norepinephrine-dopamine reuptake inhibitor (NDRI).

Duloxetine: Serotonin-norepinephrine reuptake inhibitor (SNRI).

Pharmacokinetics

Half-life: Bupropion — 21 hours; Duloxetine — 12 hours.

Chemical Properties

Molecular Formula: Bupropion — C13H18ClNO; Duloxetine — C18H19NOS.

Molecular Weight: Bupropion — 239.7420 g/mol; Duloxetine — 297.4150 g/mol.

Type: Bupropion — Small molecule; Duloxetine — Small molecule.