Bupropion vs Paroxetine

Bupropion vs Paroxetine: Overview

This comparison examines the pharmacological differences between Bupropion and Paroxetine.

Mechanism of Action

Bupropion: Norepinephrine-dopamine reuptake inhibitor (NDRI).

Paroxetine: Potent selective serotonin reuptake inhibitor with additional muscarinic and NE reuptake inhibition.

Pharmacokinetics

Half-life: Bupropion — 21 hours; Paroxetine — 21 hours.

Chemical Properties

Molecular Formula: Bupropion — C13H18ClNO; Paroxetine — C19H20FNO3.

Molecular Weight: Bupropion — 239.7420 g/mol; Paroxetine — 329.3730 g/mol.

Type: Bupropion — Small molecule; Paroxetine — Small molecule.