Canagliflozin vs Hydrochlorothiazide

Canagliflozin vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between Canagliflozin and Hydrochlorothiazide.

Mechanism of Action

Canagliflozin: Selective SGLT2 inhibitor reducing renal glucose reabsorption and lowering blood glucose.

Hydrochlorothiazide: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

Pharmacokinetics

Half-life: Canagliflozin — 10.6 hours; Hydrochlorothiazide — 6-15 hours.

Chemical Properties

Molecular Formula: Canagliflozin — C24H25FO5S; Hydrochlorothiazide — C7H8ClN3O4S2.

Molecular Weight: Canagliflozin — 444.5170 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

Type: Canagliflozin — Small molecule; Hydrochlorothiazide — Small molecule.